VLVL9X61c Internal medicine part 1 - Pneumology

Faculty of Medicine
Extent and Intensity

0/2/0. 2 credit(s). Type of Completion: z (credit).

Course objectives

At the end of the course students should be able to understand pathology and basic diferrential diagnosis of lung diseases, basic X-ray interpretation.


·        The lessons are focused on gaining both theoretical and practical experience covering the entire area of pulmonology. The practice is done at the bedside and by demonstrating different methods of examination. The theory is discussed in seminars organized in the Departments classroom. Day 1: Lung cancer. Day 2: COPD, asthma. Day 3: Tuberculosis. Day 4: Pneumonia. Day 5: Interstitial lung diseases.

Teaching methods

practical group projects, presentations by professionals in the sectors

Assessment methods

The semester is closed by completing a simple multiple-choice test covering the information presented at the seminars. A 100% participation is a precondition for granting the credit.

Further comments (probably available only in Czech)

The course can also be completed outside the examination period.
The course is taught each semester.
Information on the extent and intensity of the course: Dále klinika zajišťuje: 3 + 3 hod. - ČJ a AJ přednášek z Klinické onkologie (V. ročník), přednášku 2 hod. VI. roč., 10 seminářů VI. roč., 1 hod. před z Kl. onkologie - magistři.

VLVL9X62c Internal medicine part 2 - Cardiology and Angiology

Faculty of Medicine
Extent and Intensity

0/3/0. 4 credit(s). Type of Completion: z (credit).

Course objectives

The student should know the basic physical examination and functional tests in cardiology, should interpret ECG and recognize important arrhythmias. He/she must be able to describe basic examination in cardiology. He/she must be able to describe signs and symptoms of the most frequent cardiovascular disease, like hypertension, ischemic heart disease, myocardial infarction, arrhythmias, pulmonary embolism, peripheral artery disease, cardiogenic shock, syncope, pulmonary oedema, aortic aneurysm. He/shy must know the basic pathology of congenital and acquired valve disease, endocarditis, myocarditis and pericarditis. He/she must know the cardiovascular pharmacology as well as non-pharmacological treatment including pacing, resynchronisation and defibrillation. He/she must be able to describe the methods in invasive cardiology and cardio surgery. He/she must know the cardiovascular risk factors and to describe the pathophysiology of atherosclerosis.


·        Cardiology

Chronic coronary artery disease

stable angina pectoris, silent ischemia angina pectoris inversa, etiology, pathophysiology, differential diagnosis of the chest pain, methods of examination, risk factors, primary and secondary prevention, complications, therapy, prognosis, classification (CCSC)

Acute coronary artery disease

nonstable angina pectoris, acute myocardial infarction, sudden death, etiology and pathophysiology, methods of examination, complications, therapy, prognosis


virus, bacterial and parainfectious etiology, pathophysiology, methods of examination, complications, relation to dilated cardiomyopathy, prognosis, therapy


noninfectious, bacterial endocarditis , etiology and pathophysiology, typical forms, high risk population ( valvular disease, after valvular replacement, intravenous drug users, imunocompromised patients ), methods of exmaination, differential diagnosis, surgical vs. nonsurgical treatment, indications, prognosis.


supraventricular ( atrial fibrillation, atrial flutter, other supraventricular tachcardias ), ventricular ( ventricular tachycardia, fast ventricular tachycardia, ventricular fibrillation ), premature beats, etiology, pathophysiology, differentila diagnosis, farmacologic, nonfarmacologic treatment including radiofrequency catether ablations and implantable cardiovertors-defbillators.


sinus bradycardia, rythm of AV junction, sinoatrial arrest and block, AV block II. and III. ventricular asystole, etiology and pathophysiology, differential diagnosis, syncope, methods of examination, HUT test, farmacologic treatment, cardiac pacemaker implantation.

Left ventricular insufficiency

acute ( Killip classiffication) etiology, pathophysiology, therapy, chronic, NYHA classiffication, etiology, pathophysiology, treatment ( including heart transplantation ), prognosis.

Cor pulmonale

acute ( incl. acute pulmonary embolism ), chronic, etiology, pathophysiology, differential diagnosis primary pulmonary hypertension, therapy, prognosis

Heart valvular disease

etiology and pathophysiology, congenital, febris rheumatica, single valvular disease, multiple valvular disease, differential diagnosis, complications, farmacologic, surgical, cathetrization therapy, prognosis

Congenital valvular disease in adults

defect of atrial septum, defect of ventricular septum, Fallot tetralogy, Ebstein's anomalia, transpozition of main vessels, dustus arteriosus perzistens, etiology, pathophysiology, therapy, prognosis

Venous disease

acute vein thromboflebitis ( flebothrombosis ), etiology and pathophysiology, extraordinary forms ( phlegmasia alba and coerulea dolens ) differential diagnosis, methods of examination, complications, therapy, prevention, varicous complex, consequencies of recurrent thromboflebitis, superior and inferior vena cava syndrome.

Arterial disease

ischemic arterial disease, thrombangitis obliterans, acute peripherial artery strokes ( embolisation and thrombosis ). coarctation of the aorta, aortal dissection, etiology, pathophysiology, diferential diagnosis, methods of examination, complications, therapy, prognosis.

Arterial hypertension

essential and secondary hypertension, etiology, pathophysiology, classiffication methods of examination, complications, therapy, prognosis

Pericarditis and pericardial effusion

virus, bacterial malignant and noninfectious etiology, pathophysiology, differential diagnosis, methods of examination, complications, therapy, prognosis


deffinition, primary ( idiopathic ), secondary ( specific ), morfologic stratification, hypertrofic, dilated and restrictive ), arrhythmogenic right ventricle dysplazia, etiology pathophysiology, differential diagnosis, methods of examination, complications, therapy, prognosis

Methods of examination in cardiology

anamnesis, laboratory assesment, noninvasive methods ( electrocardiography, X ray methods, NMR, echocardiography, radionuclear methods, stress examinations, signal averaged ECG, Holter monitoring, heart rate variability, baroreflex senzitivity ), invasive ( right and left heart cathetrization, coronary angiography, eledtrophysiology, heart biopsy )


·        Vítovec, Jiří - Špinar, Jindřich. Farmakoterapie kardiovaskulárních onemocnění. Grada, 2004. 248 s.

·        Ascherman, M. a kol. Kardiologie. Galen, 2004. 1481 s.

·        Dítě, P. a kol. Vnitřní lékařství. Galen, 2007. 586 s.

·        Ischemická choroba srdeční. Edited by Jindřich Špinar - Jiří Vítovec. 1. vyd. Praha: Grada, 2003. 361 s., ob. ISBN 80-247-0500-1. info

·        SOUČEK, Miroslav, Jindřich ŠPINAR and Petr SVAČINA. Vnitřní lékařství pro stomatology. 1. vydání. Praha, 2005. 380 pp. ISBN 80-247-1367-5. info

Assessment methods

Course is organized as 10 days intership at cardiological clinics. Course is composed of collective seminars to the given topics and practical bed-side demonstrations in small groups. The condition for giving course unit credit is full attendance in all lessons and completition of final test.


VLVL9X63c Internal medicine part 3 - Nefrology, Diabetology, Revmatology and Endocrinology

Faculty of Medicine
Extent and Intensity

0/3/0. 4 credit(s). Type of Completion: z (credit).

Course objectives

After the completion of lessons the student will understand the problems of diseases taught in the block No. 3 : diabetology, nephrology, endokrinology, rheumatology. diseases of water, elektrolyte, mineral and acid-base metabolism. He/she will be able to diagnose and know the therapy of these disorders.


·        Kidney and urinary disease.

·        Laboratoty diagnostic test and clinical examination of the kidney and urinary tract diseases.

·        Glomerular diseases.

·        Nefrotic syndrome.

·        Diabetis nephropathy

·        Tumorous of the kidney and urinary tract.

·        Tubulointerstitial disease. reflux nephropathy. Renal vascular disease.

·        Acute and chronic renal failure.

·        Renal replacemet therapy.

·        Haemodialysis.

·        Renal transplantation.

·        Endokrine disease.

·        Laboratoty diagnostic test and clinical examination of the endocrine diseases.

·        Hypothalamic and pituitary disease.

·        Diabetes insipidus.

·        Acromegaly.Gigantism.

·        Hyperprolactinaemia

·        Cushing s disease.

·        Thyroid and parathyroid glands diseases.

·        Thyroid enlargement. Goitre diffuse. Solitary thyroid nodule.

·        Autoimune thyroid disease.

·        Thyrotoxicosis. Thyrotoxic crisis(thyroid storm).

·        Hypothyroidism.

·        Hypothyroidism.

·        Thyroid neoplasma.

·        The parathyroid glands disease.

·        Hyperparathyroidism, primary, secondary,tertiary.

·        Pseudohypoparathyroism

·        Adrenal glands diseases.

·        Cushing s syndrome.

·        Adrenal insufficiency.

·        Congenital adrenal hyperplasia

·        Phaeochromocytoma.

·        Neuroendokrine tumorous

·        Diabetes mellitus

·        Aetiology and pathogenesis of diabetes

·        Investigations. Insulin delivery. Insulin regimens.

·        Oral-antidiabetic drugs .

·        Diabetes mellitus typ 1 - aetiology,pathogenesis, diagnostic,therapy.

·        Diabetes mellitus typ 2 - aetiology,pathogenesis,diagnostic,therapy.

·        Diabetes in pregnancy. Gestational diabetes.

·        Diabetic ketoacidosis,

·        Nonketotic hyperosmolar diabetic coma.

·        Hypoglycaemia. Hypoglycaemic coma.

·        Management of the diabetes. Dietary management.

·        Long-term complications of diabetes

·        Diabetic retinopathy.Diabetic neuropathy.

·        The diabetic foot.

·        Inflamatory point disease.

·        Laboratoty diagnostic test and clinical examination of the inflamatory joint diseases.

·        Rheumatoid arthritis.

·        Seronegative spondylarthritis

·        Systemic connective tissue disease.

·        Systemic lupus erythematodes.

·        Systemic sclerosis

·        Polymyositis and dermatomyositis

·        Sjogren s syndrome

·        Systemic vasculitis

·        Other forms of vasculitis

·        Musculoskeleta manifestations of disease in other systems

·        Osteoporosis, osteomalacia, osteonecrosis, drug-induced lupus syndrome, myositis.

·        Psoriasis

·        Gout

·        Paget s disease

·        Osteoarthrosis. Spinal and back disease.

·        Acute rheumatic fever

·        Disorders of acid-base balance

·        Investigation of water and electrolytes

·        Metabolic acidosis, metabolic alkalosis,respiratory acidosis, respiratory alkalosis, mixed acid-base disorders

·        Disorders of amino acid metabolism

·        Metabolic disease.

·        Obesity. Hyperlipidemia. Metabolic bone disease.

·        Malabsorption.

·        Nutrition, enteral and parenteral alimentation

·        Artificial alimentation


·        Dítě, P. a kol. Vnitřní lékařství. Galen, 2007. 586 s.

·        Klener P. et all. Vnitřní lékařství Druhé doplněné vydání. Praha. Galén . 2006,

·        Souček M., et all: Vnitřní lékařství pro stomatology

·        Davidson s Principles and Practise of Medicine. 20th Edition. N.A. Boon, N.R.Colledge, B.R.Walker

Teaching methods

Lessons are taking place in blocks of 14 days. Attendance at the tuition is obligatory. The students work in groups of 5-6 members at the patient s bed step by step in all specialized department of the clinic. Expert seminars are the part of education.

Assessment methods

Succesfull writen test on problems of internal medicine – block 3 is necessary for getting the credit.The test it consist of 20 questions and the student must make out correctly 60 % of questions.

VLVL9X64c Internal medicine part 4 - Gastroenterology and Haematology

Faculty of Medicine
Extent and Intensity

0/3/0. 4 credit(s). Type of Completion: z (credit).

Course objectives

Tha main objectives can be summareized as follows. To understand the basic teaching og gastroenterology during the stay on Clinic of Internal Medicine - Gastroenterology and to understand the basis knowledge of hematology during the stay on Clinic of Internal Medicine Hematooncology.


·        Internal medical education, block IV, at IInd internal hematooncological department consists of 5 seminars and practical case presentation in patients. 1. Malignant lymphoproliferative disease, 2.Anemia. 3. Acute and chronic leukaemia. 4. Inherited and acquired coagulopathy. 4. Palliative and supportive treatment.


·        Hematologie :pro praktické lékaře. Edited by Zdeněk Adam - Jiří Vorlíček. 1. vyd. Praha: Galén, 2007. 314 s. ISBN 978-80-7262-453. info

·        ADAM, Zdeněk and Jiří VORLÍČEK. Hematologie II. Přehled maligních hematologických nemocí. Praha: Grada, 2001. 680 pp. ISBN 80-247-0116-2. info

·        ADAM, Zdeněk and Jiří VORLÍČEK. Hematologie pro praktické lékaře. 1. vyd. : Galén, 2007. 315 pp. ISBN 978-80-7262-453-9. info

·        ADAM, Zdeněk and Karel DVOŘÁK. Diagnostické a léčebné postupy u maligních chorob. Druhé,aktualizované a doplněné vydání: Přehled maligních lymfoproliferativních onemocnění dle REAL a WHO klasifikace. Praha: Grada Publishing, 2004. p. 423-433, 10 pp. ISBN 80-247-0896-5. info

·        Hematologie :přehled maligních hematologických nemocí. Edited by Zdeněk Adam - Marta Krejčí - Jiří Vorlíček. 2. vyd. Praha: Grada, 2008. 390 s., X. ISBN 978-80-247-2502. info

·        DÍTĚ, Petr and ET AL. Vnitřní lékařství. Druhé vydání. Praha: GALÉN, Na Bělidle 34, 2007. 586 pp. ISBN 978-80-7262-496-6. info

·        Hematologie 1 :neonkologická hematologie. Edited by Miroslav Penka. 1. vyd. Praha: Grada, 2001. 201 s. ISBN 80-247-0023-9. info

Assessment methods



VLVL9X66c Internal medicine part 6 - Occupational Medicine

Faculty of Medicine
Extent and Intensity

18/12. 2 credit(s). Type of Completion: k (colloquium).

Course objectives

Teaching is focused on the occupational medicine, occupational diseases and accidents at work. Students become familiar with exposure factors in the working enviroment professional in various sectors of economic activity, the methods of monitoring and evaluation as subsequent health risks. Receive information abouth the most common and serious types of damage to health from work -occupational diseases,job related injuries, work related diseases. Students get acquainted with the principles of the formation and development of selected occupational diseases, their diagnosis, treatment, prevention. They are well informed abouth the legal issues in the field ( czech list of occupational diseases, the duty doctor for suspected occupational diseases, reporting occupational diseases, social and legal consequences of recognition of occupational diseases). After successful completion of the course the student is able to: -assess and explain the relationships and connections between work activity, factors of working environment and subsequent health risks. - apply knowledge and skills gained from clinical occupational health advisory and legislation work in practice - on health at work, assessing fitness for work, organizing company preventive care, implementation of preventive examinations of workers, in preventing and rehabilitation of occupational diseases. - implement and evaluate the basic diagnostic methods in occupational medicine - spirometry, rhinomanometrie, audiometry, stress testing, EKG, finger pletysmografie, cold test. - treat the results of other objectivs investigative methods (EMG, X-ray heart, lung, three-phase scintigraphy, and allergy skin tests) in relation to the criteria of professional disease.


·        1 Introduction: The impact of work and working conditions on the health of workers. The prevention diagnostics, treatment, and medicolegal aspects of diseases caused or exacerbated by working conditions: occupational diseases, accidents at work, work-related diseases. 2 Occupational health services in the Czech Republic. Aims and functions of an occupational health service, types of service Occupational health ethics Knowledge of the work environment, specific workplace hazards Medical examinations: pre-placement, periodic and special medical examinations, occupational history, biological monitoring, medical records Treatment Health education Rehabilitation and resettlement 3 Occupational diseases and toxicology List of occupational diseases (appendix of government decree no. 290/1995) Occupational diseases due to chemical agents, poisoning by lead or a compound of lead, poisoning by a nitro- or amino- or chloroderivate of benzene or of a homologue of benzene, poisoning by organophosphates, poisoning by chemical asphyxiants (carbon monoxide, hydrogen cyanide) Occupational diseases due to physical agents, work-related cumulative trauma disorders of the hand and arm, hand-arm vibration syndrome, noise induced hearing loss, non-stochastic and stochastic health effects of ionizing radiation, dysbarism, disorders due to heat Occupational lung disorders, pneumoconioses (silicosis, coal workers pneumoconiosis, asbestosis), asthma, extrinsic allergic alveolitis (farmers lung), acute inflammation, malignancy Occupational dermatoses, primary irritant contact dermatitis, allergic contact dermatitis, neoplasms Occupational infections, infections due to exposure to infected humans or their tissues, infections transmitted from animals to humans (zoonoses), travel-associated infectious diseases 4 Mental health at work 5 The main areas of law relevant to occupational health , workers compensation law


·        Brhel P., Manoušková M., Hrnčíř. E., Pracovní lékařství. Základy primární pracovnělékařské péče, 1. vydání, Brno, NCO NZO, 2005, 338 s., ISBN 80-7013-414-3

·        BRHEL, Petr and Karel PICKA. Úvod do průmyslové toxikologie (Industrial Toxicology). 1. vydání. Brno: Masarykova univerzita, 1998. 58 pp. ISBN 80-210-1738-4. info

·        Textbook of clinical and environmental medicine. Edited by Linda Rosenstock. 2nd ed. Philadelphia: Elsevier Saunders, 2005. xviii, 133. ISBN 0-7216-8974-4. info

·        BRHEL, Petr and Viera VALKOVÁ. Occupational Disorders. (An Overview for Foreign Students; in English) (Ocupational Disorders). 1. vydání. Brno: Masarykova Universita, 1997. 40 pp. ISBN 80-210-1559-4. info

Teaching methods

The teaching contains lectures, seminars and class exercises.

Assessment methods

100% presence is required. For each issue is group discussion. Practical training - implementation and evaluation of basic diagnostic methods in occupational medicine. Final evaluation of the colloquium, an oral interview of one of the 23 questions.

LVL7X65c Internal medicine part 5 - Functional Diagnostics and Rehabiliation

Faculty of Medicine
Extent and Intensity

0/3/0. 2 credit(s). Type of Completion: z (credit).

Course objectives

This course unit provides detailed information about key diagnostic functional tests in clinical medicine, all of which are conducted inside the lab. Students will be able to apply the basic concepts by conducting self-made examinations and recording their own physiological responses to exercise. Students can further understand the human body’s ability to perform exercise, to adapt to stressful conditions, to improve the exercise performance, to design appropriate therapeutic exercise rehabilitation programs and to evaluate the outcomes. All the topics are presented using a variety of teaching methods, including lectures, seminars, group activities, practical work and a tutorial. All lectures and seminars offer also the comprehensive resource that frames the latest and most significant research findings and makes it easier for students to learn.


·        The part of the teaching programme of internal medicine

·        1 Introduction

·        2 Reaction and adaptation to physical stress

·        2.1 Gas transport system

·        2.1.1 Respiration

·        2.1.2 Circulation

·        2.2 Energy metabolism

·        2.3 Body fluids and ions, acid - base balance

·        2.4 Neuromuscular system

·        3 Stress tests

·        3.1 Characteristics

·        3.2 Indications and contraindications

·        3.3 Stress testing procedure

·        3.4 Criteria of evaluation and interpretation

·        3.5 Methods

·        3.6 Special approaches to stress testing

·        3.6.1 Stress testing in children and adolescents

·        3.6.2 Stress testing in clinical diagnostics

·        3.6.3 Stress testing in therapeutical and rehabilitation programmes

·        3.6.4 Stress testing in different groups of population

·        4 Fundamentals of exercise therapy and rehabilitation

·        4.1 Exercise therapy as a part of rehabilitation

·        4.1.1 Definition and division into constituent parts

·        4.1.2 Therapeutical rehabilitation

·        4.2 Prescription of exercise therapy

·        4.2.1 Principles

·        4.2.2 Physiologic efficiency of physical activities

·        4.2.3 Kinds of physical activities

·        4.2.4 Stress intensity

·        4.2.5 Frequency and duration of stress

·        5 Stress testing and exercise therapy in selected diseases

·        5.1 Cardiovascular and haematologic diseases

·        5.1.1 Functional disorders of circulation

·        5.1.2 Congenital heart diseases

·        5.1.3 Valvular heart diseases

·        5.1.4 Acute inflammatory diseases

·        5.1.5 Cardiomyopathy

·        5.1.6 Atherosclerosis

·        5.1.7 Coronary artery diseases

·        5.1.8 Heart failure

·        5.1.9 Arrhythmias

·        5.1.10 Arterial hypertension

·        5.1.11 Chronic ischaemic arterial obstructive disease of lower limbs

·        5.1.12 Anaemia

·        5.2 Pulmonary diseases

·        5.2.1 Bronchial asthma

·        5.2.2 Chronic obstructive pulmonary disease

·        5.2.3 Interstitial lung diseases

·        5.2.4 Cystic fibrosis

·        5.3 Gastrointestinal diseases

·        5.3.1 Peptic ulcer

·        5.3.2 Constipation

·        5.3.3 Hepatitis

·        5.4 Metabolic, nutritional and endocrine diseases and disorders

·        5.4.1 Obesity (exgenous, alimentary)

·        5.4.2 Malnutrition (protein - energy type)

·        5.4.3 Anorexia nervosa

·        5.4.4 Diabetes mellitus

·        5.4.5 Thyropathy

·        5.5 Other diseases and disorders

·        5.5.1 States after cytostatic therapy in children

·        5.5.2 Renal diseases

·        5.5.3 Osteoporosis

·        5.5.4 Arthropathy

·        5.6 Case presentations

·        5.6.1 Heart failure and coronary artery disease

·        5.6.2 Bronchial asthma

·        5.6.3 Diabetes mellitus

·        5.6.4 Other current cases


·        PLACHETA, Z. - SIEGELOVÁ, J. - ŠTEJFA, M. a kol. Zátěžová diagnostika v ambulantní a klinické praxi. 1. vyd. Praha : Grada, 1999. 276 s. ISBN 80-7169-271-9 (2. vyd. 2001)

·        PLACHETA, Z. a kol. Zátěžové vyšetření a pohybová léčba ve vnitřním lékařství. Brno : MU, 2001. 179 s. ISBN 80-210-2614-6

Teaching methods

Lessons are taking place in blocks of one week. Attendance at the tuition is obligatory. The students work in groups of 5-6 members at the patient s bed. Expert seminars are the part of education.

Assessment methods

written test at the end of the course


VLVL101p Internal medicine - lecture

Faculty of Medicine
Extent and Intensity

0/0. 0 credit(s). Type of Completion: -.

Course objectives

Particulars lectures about special problems in Internal Medicine.


·        Heart failure

·        Echocardiography

·        Therapy of bradycardia, pacemackers

·        Unstable angina

·        Functional gastrointestinal disease

·        Nonfarmacology therapy of tachyarytmias

·        Disorders of acid-base balance

·        Kidney and farmakotherapy of Internal diseases

·        Cardiovascular diseases and chronic stress

·        Hypertension therapy

·        Iodine-associated thyroid disease

·        Management of treatment typ 2 diabetes

·        Peptic ulcer disease

·        Inflamatory bowel disease

·        Genetics and arrhytmia

·        Nutrition enteral and parenteral


·        Souček M., et all: Vnitřní lékařství pro stomatology

·        Dítě Petr et all :Vnitřní lékařství Druhé,doplněné a přepracované vydání

·        Klener P. et all. Vnitřní lékařství Druhé doplněné vydání. Praha. Galén . 2006,

·        Davidson s Principles and Practise of Medicine. 20th Edition. N.A. Boon, N.R.Colledge, B.R.Walker

Teaching methods


Assessment methods

Lectures are selective,optional.