In this year’s InGA Start-up call, a total of 35 projects competed, of which the Board of the Internal Grant Agency of the Faculty of Medicine decided to support the following 10 projects:
- Eliška Zgarbová: "Bridging Stem Cells and Patients: Establishing iPSC- and Patient-Derived in vitro Organoid Models of IBD"
- Francisco Molina Gambin: "Developing a first-in-human model to study light-induced ciliary trafficking in retinal ciliopathies"
- Jiří Hradil: "Colorectal cancer tumoroids: 3D in vitro model for the evaluation of the therapeutic potential of schizophyllan-oxaliplatin conjugates"
- Kateřina Vašíčková: "Development of pluripotent stem cell–based expandable pancreatic progenitors to model tumor initiation and immuno-stromal interactions"
- Polina Navrátilová: "Impact of Chondroprotective Therapy on Inflammation and Cartilage Microstructure in Osteoarthritis: Integrating MRI and Molecular Insights"
- Zdeněk Chovanec, Jan Resler: "Resler Comparative analysis of subpleural lung nodules marking dyes - in vivo animal experiment on domestic pig"
- Vít Weinberger, Libor Viktora: "Ascitoids - predictive models for individualized ovarian cancer therapy using ascites-derived organoids"
- Lucie Ráčková: "Exploring Melatonin, and Low-Dose Radiation Preconditioning as Countermeasures Against Simulated Galactic Cosmic Ray Exposure: A CNS Study Using Zebrafish"
- Gottumukkala Narendra Varma: "Mitochondrial Heist: Investigating the tunneling nanotube mediated preferential targeting of 4-1BB CD19-CAR T-cells for mitochondrial theft by CLL Cells"
- Veronika Brezáni: "Crosstalk between delta opioid receptors and inflammatory mediators in primary sensory neurons: An in vitro study of priming and intracellular trafficking"
In the LF Accelerate call, 8 project proposals were submitted in total. External reviewers, in cooperation with the InGA Board, selected the 2 best:
- Eliška Zgarbová: "Development of a Modular Microfluidic Chamber for Advanced 3D Organoid Culture and Anti-Fibrotic Drug Testing"
- Jiří Kos: "Novel Inhaled Antibacterial Remedies for Multidrug-Resistant Pulmonary Diseases"
Congratulations to all successful applicants!