Project information
Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology

Project Identification

KJB501620601

Project Period

2/2006 - 12/2008

Investor / Pogramme / Project type

Academy of Sciences of the Czech Republic

The research grant projects for juniors

MU Faculty or unit

Faculty of Medicine

Keywords

RAGE, haplotype, promotor, diabetes

Formation of Advanced Glycation End-products (AGEs) and subsequent activation of the Receptor of AGEs (RAGE) represents one of the principal pathogenic mechanisms of hyperglycaemia-induced cell damage.

Publications

Total number of publications: 15

2010

Crohn's disease activity versus extent of DNA damage/repair and variability in the RAGE gene

PÁCAL Lukáš VARVAŘOVSKÁ Jana SÝKORA Josef KOŽELUHOVÁ Jana RUŠAVÝ Zdeněk RACEK Jaroslav ŠTĚTINA Rudolf KAŇKOVÁ Kateřina

Article in Periodical

Scripta Medica, year: 2010, volume: 83/2010, edition: 1
Functional analysis of the common haplotype in the Receptor for Advanced Glycation End-products gene previously identified as a susceptibility factor for diabetic nephropathy

KAŇKOVÁ Kateřina BENEŠ Petr KUCHTÍČKOVÁ Šárka

Article in Periodical

Experimental and Clinical Endocrinology & Diabetes, year: 2010, volume: 118, edition: 2

2008

Diabetic threesome (hyperglycemia, renal function and nutrition) and advanced glycation end products: evidence for the multiple-hit agent?

KAŇKOVÁ Kateřina

Article in Periodical

Proceedings of the Nutrition Society, year: 2008, volume: 67, edition: 1
Diabetická nefropatie- renální funkce a hladina sRAGE, genet. variabilita AGER genu

KRUSOVÁ Darja KAŇKOVÁ Kateřina KALOUSOVÁ Marta HERTLOVÁ Miluše ZIMA Tomáš

Conference abstract

Year: 2008, type: Conference abstract
Diabetická nefropatie, solubilní RAGE a genetická variabilita AGER genu

KRUSOVÁ Darja KAŇKOVÁ Kateřina KALOUSOVÁ Marta HERTLOVÁ Miluše ZIMA Tomáš

Conference abstract

Year: 2008, type: Conference abstract
Functional analysis of the susceptibility haplotype in the Receptor for Advanced Glycation End-products gene and its role in the hyperglycemia-driven pathology

KAŇKOVÁ Kateřina BENEŠ Petr KUCHTÍČKOVÁ Šárka

Conference abstract

Year: 2008, type: Conference abstract
Promotor and intron variants in the RAGE gene influence its transcriptional activity

KAŇKOVÁ Kateřina BENEŠ Petr KUCHTÍČKOVÁ Šárka

Conference abstract

Year: 2008, type: Conference abstract
RAGE gene variants and disease activity in young and adult patients with Crohn disease

KAŇKOVÁ Kateřina VARVAROVSKA Jana PÁCAL Lukáš

Conference abstract

Year: 2008, type: Conference abstract
Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene

KAŇKOVÁ Kateřina KALOUSOVA Marta HERTLOVÁ Miluše KRUSOVÁ Darja OLŠOVSKÝ Jindřich ZIMA Tomáš

Article in Periodical

Arch Physiol Biochem, year: 2008, volume: 114, edition: 2

2007

Haplotype-based association study between the region of 6p chromosome spanning the AGER - TNFA - LTA - NFKBIL1 - BAT1 and diabetic nephropathy

KAŇKOVÁ Kateřina PÁCAL Lukáš STEJSKALOVÁ Andrea KRUSOVÁ Darja HERTLOVÁ Miluše

Conference abstract

Year: 2007, type: Conference abstract