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Project information
Molecular pathophysiology of selected multigenic related to civilization diseases

Project Identification
VS96097
Project Period
7/1996 - 12/2000
Investor / Pogramme / Project type
Ministry of Education, Youth and Sports of the CR
  • Support to University Research Programmes
MU Faculty or unit
Faculty of Medicine
Keywords
genetics of multigenic diseases, candidate gene approach, case-control study, intermediate phenotypes, essential hypertension, late complications of diabetes mellitus, atopic diseases, metastatic growth, malignant tumors, genetic associations

An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes.A "case-control" study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common "civilization" diseases,as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods.It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied.

Publications

Total number of publications: 75

2000

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