Project information
Vysoce efektivní systém založený na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako terapeutického cíle pro Alzheimerovu chorobu (Alzheimer)

Information

This project doesn't include Faculty of Medicine. It includes Faculty of Science. Official project website can be found on muni.cz.

Project Identification

GA16-06106S

Project Period

1/2016 - 12/2018

Investor / Pogramme / Project type

Czech Science Foundation

Standard Projects

MU Faculty or unit

Faculty of Science

prof. RNDr. Zdeněk Glatz, CSc.

Hlavním cílem tohoto projektu je vývoj vysoce efektivního systému založeného na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako potenciálního terapeutického cíle pro léčbu Alzheimerovy choroby.

Publications

Total number of publications: 41

2017

Beta-secretase kinetics detected by MALDI TOF MS

MACHÁLKOVÁ Markéta SCHEJBAL Jan GLATZ Zdeněk PREISLER Jan

Conference abstract

Year: 2017, type: Conference abstract
Capillary electrophoresis-integrated immobilized enzyme reactor for screening of β-secretase inhibitors – potential anti-Alzheimer’s disease drugs

SCHEJBAL Jan ŠEFRANÁ Šárka GLATZ Zdeněk

Conference abstract

Year: 2017, type: Conference abstract
Capillary electrophoresis-integrated immobilized enzyme reactor for β-secretase enzyme assays

SCHEJBAL Jan ŠEFRANÁ Šárka GLATZ Zdeněk

Conference abstract

Year: 2017, type: Conference abstract
CE-C4D method for determination of beta-secretase activity as a tool for unbiased screening of potential drugs for patients suffering from Alzheimer’s disease

MÁDR Aleš CELÁ Andrea SCHEJBAL Jan JUŘICA Jan ŘEMÍNEK Roman GLATZ Zdeněk

Conference abstract

Year: 2017, type: Conference abstract
Development and comprehensive comparison of two on-line capillary electrophoretic methods for beta-secretase inhibitor screening

ŘEMÍNEK Roman SLEZÁČKOVÁ Lucie SCHEJBAL Jan GLATZ Zdeněk

Article in Periodical

Journal of Chromatography A, year: 2017, volume: 1518, edition: October, DOI
METABOLIC RATIOS OF LANSOPRAZOLE TO 5-HYDROXYLANSOPRAZOLE AND LANSOPRAZOLE TO LANSOPRAZOLE SULFONE FOR PREDICTION OF CYP2C19 AND CYP3A4 METABOLIC ACTIVITY

JUŘICA Jan KOSTOLANSKÁ Katarína PEŠ Ondřej HLINOMAZ Ota MÁCHAL Jan

Conference abstract

Year: 2017, type: Conference abstract
New IMER setup for metabolic studies in capillary electrophoresis using magnetic microparticles

RAMANA Pranov SCHEJBAL Jan ADAMS Erwin AUGUSTIJNS Patrick GLATZ Zdeněk VAN SCHEPDAEL Ann

Year: 2017, type:
β-secretase enzyme assay by MALDI TOF MS

MACHÁLKOVÁ Markéta SCHEJBAL Jan GLATZ Zdeněk PREISLER Jan

Conference abstract

Year: 2017, type: Conference abstract

2016

BACE enzyme kinetics detected by MALDI TOF mass spectrometry

MACHÁLKOVÁ Markéta SCHEJBAL Jan GLATZ Zdeněk PREISLER Jan

Article in Proceedings

CECE 2016, year: 2016
Bile Acids, Nuclear Receptors and Cytochrome P450

JUŘICA Jan DOVRTĚLOVÁ Gabriela NOSKOVÁ Kristýna ZENDULKA Ondřej

Article in Periodical

Physiological Research, year: 2016, volume: 65, edition: Suppl. 4