Czech Infrastructure for Integrative Structural Biology (CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Publications
Total number of publications: 178
2022
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A GP1BA Variant in a Czech Family with Monoallelic Bernard-Soulier Syndrome
International Journal of Molecular Sciences, year: 2022, volume: 23, edition: 2, DOI
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A large-scale assay library for targeted protein quantification in renal cell carcinoma tissues
Proteomics, year: 2022, volume: 22, edition: 7, DOI
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A release of Ti-ions from nanostructured titanium oxide surfaces
Surfaces and Interfaces, year: 2022, volume: 29, edition: April 2022, DOI
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Aminophylline Induces Two Types of Arrhythmic Events in Human Pluripotent Stem Cell–Derived Cardiomyocytes
Frontiers in Pharmacology, year: 2022, volume: 12, edition: January, DOI
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Atomic Force Spectroscopy is a promising tool to study contractile properties of cardiac cells
Micron, year: 2022, DOI
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Cancer cell viscoelasticity measurement by quantitative phase and flow stress induction
Biophysical Journal, year: 2022, volume: 121, edition: 9, DOI
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Celleriite, ☐(Mn22+Al)Al6(Si6O18)(BO3)3(OH)3(OH), a new mineral species of the tourmaline supergroup
American Mineralogist, year: 2022, volume: 107, edition: 1, DOI
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Comparative analysis of transcriptomic points-of-departure (tPODs) and apical responses in embryo-larval fathead minnows exposed to fluoxetine
ENVIRONMENTAL POLLUTION, year: 2022, volume: 295, edition: FEB, DOI
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Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin
Computational and Structural Biotechnology Journal, year: 2022, volume: 20, edition: May 2022, DOI
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Critical interactions of neuronal transcription factor REST with stabilizer TRF2
Year: 2022, type: Conference abstract