Czech Infrastructure for Integrative Structural Biology (CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
-
Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 262
2023
-
Cardiovascular Diseases
Mechanics in Diseased Cells and Tissues, Volume 2 Biomedical Applications, year: 2023, number of pages: 26 s.
-
Catechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer
Scientific Reports, year: 2023, volume: 13, edition: 1, DOI
-
Convergent Assembly of the Tricyclic Labdane Core Enables Synthesis of Diverse Forskolin-like Molecules
Angewandte Chemie International Edition, year: 2023, volume: 62, edition: 1, DOI
-
Digital and Analog Detection of SARS-CoV-2 Nucleocapsid Protein via an Upconversion-Linked Immunosorbent Assay
Analytical Chemistry, year: 2023, volume: 95, edition: 10, DOI
-
Electron microscopy reveals toroidal shape of master neuronal cell differentiator REST – RE1-silencing transcription factor
Computational and Structural Biotechnology Journal, year: 2023, volume: 21, edition: Dec, DOI
-
Irradiation potentiates p53 phosphorylation and p53 binding to the promoter and coding region of the TP53 gene
Biochimie, year: 2023, volume: 204, edition: January, DOI
-
Nature of NMR Shifts in Paramagnetic Octahedral Ru(III) Complexes with Axial Pyridine-Based Ligands
Inorganic Chemistry, year: 2023, volume: 62, edition: 8, DOI
-
Staphylococcus aureus Prophage-Encoded Protein Causes Abortive Infection and Provides Population Immunity against Kayviruses
mBio, year: 2023, volume: 14, DOI
-
Targeting undruggable oncoproteins c-Myc and N-Myc by the 9aaTADs
Year: 2023, type: Appeared in Conference without Proceedings
-
The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD
The Biochemical journal, year: 2023, DOI