Project information
Vliv pneumologické medikace na funkce lidských kardiomyocytů
- Project Identification
- NU20-06-00156
- Project Period
- 5/2020 - 12/2023
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Faculty of Medicine
- Cooperating Organization
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University Hospital Brno-Bohunice
- Responsible person doc. MUDr. Kristián Brat, Ph.D.
Projekt se bude zabývat mechanizmem vzniku kardiomyopatie působením kombinací bronchodilatačních léčiv, za použití kardiomyocytů odvozených z pluripotentních kmenových buněk, získaných reprogramací primárních kultur z biopsií pacienů.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 20
2022
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Změny elektromechanických vlastností lidských kardiomyocytů v prostředí běžně užívaných bronchodilatancií – aminophyllin, salbutamol, ipratropium
Year: 2022, type: Appeared in Conference without Proceedings
2021
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[P3.065] Biomechanical drug testing by atomic force microscopy combined with human pluripotent stem cell derived cardiomyocytes
Year: 2021, type: Conference abstract
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Arrhythmic events in clustered human pluripotent stem cell-derived cardiomyocytes
Year: 2021, type: Conference abstract
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Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem Cells
Frontiers in Cell and Developmental Biology, year: 2021, volume: 8, edition: JAN 2021, DOI
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Cell based AFM biosensensing for screening of pulmonary-drug related arrhytmic effects
Nanocon 2020, year: 2021
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Cellular pathology of the human heart in Duchenne muscular dystrophy (DMD): lessons learned from in vitro modeling
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, year: 2021, volume: 473, edition: 7, DOI
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Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids
International Journal of Molecular Sciences, year: 2021, volume: 22, edition: 2, DOI
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Super-resolution microscopy of chromatin fibers and quantitative DNA methylation analysis of DNA fiber preparations
Journal of Cell Science, year: 2021, volume: 134, edition: 15, DOI
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TIME-LAPSE MONITORING OF CELL MECHANICAL PROPERTIES
CONFERENCE PROCEEDINGS - NANOCON 2020, year: 2021
2020
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TIME-LAPSE MONITORING OF CELL MECHANICAL PROPERTIES
Nanocon 2020, year: 2020