Quantification of the neurodegeneration associated proteins in drug-resistant temporal lobe epilepsy

Project Identification
MUNI/11/SUP/11/2020
Project Period
1/2021 - 12/2021
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Cognitive decline in temporal lobe epilepsy (TLE) and high prevalence of epilepsy in Alzheimer dementia point to the bidirectional relationship between neurodegeneration and epilepsy. Current pilot project aims to study the process of neurodegeneration represented by accumulation of specific proteins in the context of TLE. New immunohistochemical methods will be implemented and optimized on previously collected resection brain tissue samples, subsequently will be performed semi-quantitative analyses for presence of selected proteins and correlation of the results with clinical data. Presented project will bring cooperation of three departments of Saint Anne's University Hospital and establish novel cooperation with a renowned epilepsy team from Universitätsklinikum Freiburg, Germany. This is an unprecedented opportunity to implement a novel method on the already existing dataset for innovative research question in the context of expert teams from two excellent institutions.

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