Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (DBS3D)
- Project Identification
- GA21-25953S
- Project Period
- 1/2021 - 12/2023
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
-
Institute of Scientific Instruments of the ASCR, v. v. i.
- Responsible person Ing. Pavel Jurák, CSc.
The main aim of the project is to study cortico-subcortical interactions via advanced analysis of electrophysiological phenomena from microrecording to the whole brain levels. These interactions are basis for the understanding of the brain’s functioning, particularly in its pathological alterations; To investigate brain electrical activity in diseases involving both cortical and subcortical structures, i.e. with primarily subcortical pathology (Parkinson’s Disease) and primarily cortical pathology (Epilepsy). To identify electrophysiological phenomena related to DBS therapy with the main focus on possible predictive biomarkers. To follow up our pilot data defining optimal and suboptimal response to DBS in a long-term neuropsychological observation.
Publications
Total number of publications: 5
2021
-
Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease
Human Brain mapping, year: 2021, volume: 42, edition: 17, DOI
-
Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges
Journal of Neural Transmission, year: 2021, volume: 128, edition: 8, DOI
-
Ictal connectivity changes induced by pulvinar stimulation correlate with improvement of awareness
Year: 2021, type: Article in Periodical (without peer review)
-
Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study
BRAIN TOPOGRAPHY, year: 2021, volume: 34, edition: 3, DOI
-
Thalamic oscillatory activity may predict response to deep brain stimulation of the anterior nuclei of the thalamus
Epilepsia, year: 2021, volume: 62, edition: 5, DOI