Mechanisms of renoprotective effect of SGLT2 inhibition in T2DM patients

Project Identification
Project Period
1/2022 - 12/2023
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

The project aims to contribute to the understanding of renoprotective effect of gliflozins, a new class of antidiabetic drugs. Two approaches are planned: (1) an observational study of T2DM patients who are eligible for gliflozin treatment on top of the current antidiabetic treatment and (2) in vitro analysis of human-derived proximal tubular epithelial cells. Specific molecular pathways studied include dicarbonyl stress and cell death pathways.

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