Introduction of a clinically relevant avian chorioallantoic membrane model in cancer research with a focus on migration and metastatic potential of tumor cells and tumor angiogenesis
- Project Identification
- Project Period
- 1/2023 - 12/2023
- Investor / Pogramme / Project type
- Masaryk University
- MU Faculty or unit
- Faculty of Medicine
Many promising drugs discovered in preclinical in vitro studies failed to fulfil the awaited clinical outcomes as these studies mostly focus on inadequate models. Being naturally immunodeficient, the chick embryo may receive cells derived from tumour tissues of cancer patients and/or model cell lines and serve as a clinically relevant in vivo model. The assessment of the treatment response in the chick ChorioAllantoic Membrane (CAM) model can represent a useful screening tool for personalized medicine with the potential to improve patient management and treatment outcome. Destruction of the basement membrane can be easily visualized and tumour growth, invasion into the connective tissue, and metastasis can be accurately quantified in CAM assay, making CAM a valuable model for investigating cancer progression. In conclusion, the CAM assay is an attractive in vivo model that is simple, reproducible, and has many applications, including the study of tumour invasion, metastasis, angiogenesis, and screening for novel drugs.
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