The project focuses on one of the most fundamental processes in biology: the accurate copying of genetic information. Every time a cell divides, its DNA must be replicated precisely to ensure that the newly formed cells receive a complete and correct copy of the genome. Errors in this process can lead to genome instability, a hallmark of many human diseases, including cancer.
The research team is investigating the role of RECQ4, a protein which plays a crucial role in initiating DNA replication and maintaining genome stability. Mutations in the RECQ4 gene are associated with several rare genetic disorders, including Rothmund-Thomson syndrome, and overexpression of RECQ4 has been reported in a range of human cancers. Despite its importance, many aspects of RECQ4 function remain poorly understood.
To address these questions, the project combines expertise from biochemistry, biophysics, structural biology, cell biology, and genetics. Dr. Bose will use advanced imaging methods, single-molecule approaches, proteomics, and in vitro reconstitution techniques to study RECQ4 function across multiple levels of biological organisation.
Beyond advancing our understanding of how human cells duplicate their genomes, the project may provide new insights into the molecular mechanisms underlying genome instability disorders and cancer. While the research is primarily fundamental in nature, improved knowledge of RECQ4 function could contribute to future efforts aimed at developing more targeted therapeutic strategies.
The project will benefit from a network of international collaborations and specialised research stays in partner laboratories, enabling the exchange of expertise and the application of cutting-edge methodologies.
The ReG4CoRe project represents another step towards understanding the molecular mechanisms that safeguard our genetic information and how their failure can contribute to human disease.
