Lysosomal pathway of the TRAIL-induced apoptosis in breast carcinoma cells-the role of the lysosomal protease cathepsin D

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Authors

JANČEKOVÁ Blanka ONDROUŠKOVÁ Eva KNOPFOVÁ Lucia BENEŠ Petr ŠMARDA Jan

Year of publication 2013
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Science

Citation
Description In this study, we investigated the role of lysosomal aspartyl protease cathepsin D (CTSD( in the TRAIL-induced apoptosis. We showed that overexpression of CTSD sensitizes MDA-MB-231 breast carcinoma cells to the TRAIL-induced apoptosis in enzymatic activity-dependent manner. The increased frequency fo apoptosis observed in the CTSD-overexpressing cells corresponded to caspase activation and cleavage of the Bid protein, the pro-apoptotic BCL-2 family member. We also showed that the CTSD-mediated pro-apoptotic effect can be partially reversed by the caspase 8 and aspartyl protease inhibitors.
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