Studie možnosti mapování vybraných léčiv v mozkové tkáni myší pomocí MALDI MS

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Title in English Study of MALDI MS imaging of selected drugs in brain tissue of mice
Authors

JÄGEROVÁ Kateřina BEDNAŘÍK Antonín NILSSON Christian POKORNÁ Soňa ILKOVICS Ladislav HAMPL Aleš PISTOVČÁKOVÁ Jana DEMLOVÁ Regina PREISLER Jan

Year of publication 2013
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Citation
Description Matrix-assisted laser desorotion/ionization mass spektrometry (MALDI-MS) is a technique allowing the visualization of the distribution of analytes variety in diverse samples, typicaly in thin sections of biological tissue. This method has been successfully used to the analysis of brain tissues, monitoring of drugs distribution and drugs metabolites in tissues, and in new biomarkers investigation. In this paper, we research the imaging of selected drugs distribution - olanzapin, haloperidol and paliperidone in tissue of mice brain using MALDI MS.
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