Kolaterální cirkulace mozku - potenciální cíl terapie mozkových infarktů
| Title in English | Cerebral Collateral Circulation - Potential Target of Cerebral Infarction Management |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | stroke; collateral circulation; reperfusion; induced hypertension |
| Description | Leptomeningeal (pial) collaterals are native anastomoses that cross-connect the distal-most arterioles within the branches of the main cerebral arteries. They represent a potential emergency backdoor to maintain blood flow to the brain during an acute ischemic stroke. In addition, support of collateral circulation represents an attractive concept of stroke therapy. So far, neurologists mostly paid attention to recanalization therapies but neglected cerebral collateral circulation as a therapeutic target. This theme is very topical not only for cerebrovascular neurologists. The purpose of this article is to summarize information on a) anatomy and (patho)physiology of cerebral collateral circulation, b) diagnostics of collateral circulation including scoring systems using widely-available CT angiography, and c) pharmacological and non-pharmacological therapies aimed at augmenting cerebral collateral circulation. |