A Simple Model to Assess the Probability of Invasion in Ductal Carcinoma In Situ of the Breast Diagnosed by Needle Biopsy

• Authors: COUFAL Oldřich; SELINGEROVÁ Iveta; VRTĚLOVÁ Pavlína; KRSIČKA Petr; GABRIELOVÁ Lucie; FABIAN Pavel; STÍSKALOVÁ Kateřina; SCHNEIDEROVÁ Monika; POPRACH Alexandr; JUSTAN Ivan
• Year of publication: 2014
• Type: Article in Periodical
• Magazine / Source: BIOMED RESEARCH INTERNATIONAL
• MU Faculty or unit: Faculty of Science
• Web: http://www.hindawi.com/journals/bmri/2014/480840/
• Doi: http://dx.doi.org/10.1155/2014/480840
• Field: Applied statistics, operation research
• Keywords: Breast carcinoma; simple model
• Description: Objectives. The aim of the study was to develop a clinical prediction model for assessing the probability of having invasive cancer in the definitive surgical resection specimen in patients with biopsy diagnosis of ductal carcinoma in situ (DCIS) of the breast, to facilitate decision making regarding axillary surgery. Methods. In 349 women with DCIS, predictors of invasion in the definitive resection specimen were identified. A model to predict the probability of invasion was developed and subsequently simplified to divide patients into two risk categories.The model’s performance was validated on another patient population.

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