Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes
| Authors | |
|---|---|
| Year of publication | 2018 |
| Type | Article in Periodical |
| Magazine / Source | BMC Research Notes |
| MU Faculty or unit | |
| Citation | |
| Web | https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-3106-7 |
| Doi | http://dx.doi.org/10.1186/s13104-017-3106-7 |
| Keywords | Genome sequencing; Phylogenetic analysis; Single nucleotide variant; SyphilisTreponema pallidum |
| Description | Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis. Genetic analyses of TPA reference strains and human clinical isolates have revealed two genetically distinct groups of syphilis-causing treponemes, called Nichols-like and SS14-like groups. So far, no genetic intermediates, i.e. strains containing a mixed pattern of Nichols-like and SS14-like genomic sequences, have been identified. Recently, Sun et al. (Oncotarget 2016. https://doi.org/10.18632/oncotarget.10154) described a new “phylogenetic group” (called Lineage 2) among Chinese TPA strains. This lineage exhibited a “mosaic genomic structure” of Nichols-like and SS14-like lineages. |
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