Generation of human iPSCs from human prostate cancer-associated fibroblasts IBPi002-A

Authors

KAHOUNOVÁ Zuzana SLABÁKOVÁ Eva BINÓ Lucia REMŠÍK Ján FEDR Radek BOUCHAL Jan KURFŰRSTOVÁ Daniela VRTĚL Radek ŠTUDENT Vladimír JUREČKOVÁ Lucie POROKH Volodymyr HAMPL Aleš SOUČEK Karel

Year of publication 2018
Type Article in Periodical
Magazine / Source Stem Cell Research
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S1873506118302757?via%3Dihub
Doi http://dx.doi.org/10.1016/j.scr.2018.11.006
Keywords prostate cancer
Description A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5 (TM) Episomal iPSC Reprogramming Kit. Pluripotency of the derived transgene-free iPS cell line was confirmed both in vitro by detecting expression of factors of pluripotency on a single-cell level, and also in vivo using teratoma formation assay. This new iPS cell line may be used for differentiation into different prostate-specific cell types in differentiation studies.
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