Faktory ovlivňující eliminaci léčiv u pacientů podstupujících extrakorporální náhradu renálních funkcí
| Title in English | Factors affecting drug elimination during the renal replacement therapy |
|---|---|
| Authors | |
| Year of publication | 2018 |
| Type | Article in Periodical |
| Magazine / Source | časopis Remedia |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.medvik.cz/link/bmc18026395 |
| Description | Renal insufficiency is a significant factor affecting body’s ability to maintain the internal homeostasis. In clinically defined cases, renal replacement therapy is required. Technical methods allow not only the elimination of toxic metabolites but also the elimination of certain drugs. According to this, it is crucial to determine the drug cummulation risk. In addition, quantitative drug clearance provided by the elimination method is as much relevant in order to provide dose and interval adjustment. To estimate drug elimination, both properties of the elimination methods and pharmacokinetic parameters of the drug should be taken into account. |