Možnosti léčby farmakorezistentní schizofrenie v běžné klinické praxi
| Title in English | Treatment possibilities of pharmaco-resistant schizofrenie in common clinical practice |
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| Authors | |
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie pro praxi |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.solen.cz/artkey/psy-202002-0004_moznosti_lecby_farmakorezistentni_schizofrenie_v_bezne_klinicke_praxi.php?back=%2Fsearch.php%3Fquery%3Dfarmakoterapie%252520v%252520t%2525C3%252520%2525C2%252520hotenstv%2525C4%252520%2525C2%2525AD%26sfrom%3D11 |
| Keywords | pharmaco-resistant schizophrenia; clozapine; augmentation; combination of antipsychotics |
| Description | The paper is focused on available therapeutic approaches to schizophrenia in common clinical practice. The literature and clinical experience stress the exclusion of pseudoresistance, caused mainly by nonadherence. The gold standard is clozapine. Further possibilities include augmentation and combination of antipsychotics; however, for these strategies there is not enough evidence and results are inconsistent. Augmentation is aimed mostly on persistent and dominant symptoms (depressive and negative symptoms, cognitive deficit). The most frequently used combination is combination of clozapine with an antipsychotic with complementary pharmacological profile. |