Chronická pankreatitida - rizikový faktor karcinomu pankreatu
| Title in English | Chronic pancreatitis - a risk factor of pancreatic carcinoma |
|---|---|
| Authors | |
| Year of publication | 2020 |
| Type | Article in Periodical |
| Magazine / Source | Gastroenterol prax |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.amedi.sk/chronicka-pankreatitida-rizikovy-faktor-karcinomu-pankreatu-a9048,9033,8.html |
| Keywords | chronic pancreatitis; chronic inflammation; mediators of inflammation; adipocytokines; pancreatic cancer |
| Description | Chronic inflammation is a possible risk factor in carcinoma induction. In gastroenterology, there are known terms, e.g. chronic gastritis - gastric carcinoma, chronic hepatitis – cirrhosis of the liver – hepatocellular carcinoma, or colitis – large intestine carcinoma. The same is valid for people with chronic pancreatitis, regardless of aetiology of pancreatitis. Even alcohol seems to be an especially risky factor, and origination of pancreatic carcinoma is extremely frequent in people with hereditary pancreatitis. The risk of pancreatic carcinoma origination in people with chronic pancreatitis is growing with the length of its duration. Adipocytokines belong among new factors which might significantly contribute to the process of carcinogenesis in the terrain of chronic inflammation, or chronic pancreatitis, especially in obese patients. As obesity is one of the factors of pancreatic carcinoma origination, recently significant attention is paid to these substances. Pancreatic carcinoma still belongs to the permanent challenges in gastroenterology. Its mostly late diagnosis, creation of metastases in an already small tumour are essential factors why 5-year survival in people with carcinoma belongs to one of the lowest not only among oncologic diseases in gastroenterology. Therefore, identification of tumorous disease in endangered people comes into consideration as one of the most effective approaches not only regarding an early diagnosis but also effective therapy. |