Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease

Authors

KHAIRNAR Amit Suresh RUDÁ Jana ARAB Anas HADJISTYLLIS Constantinos ŠEJNOHA MINSTEROVÁ Alžběta SHANG Qi CHOVSEPAIN Alexandra DRAŽANOVÁ Eva SZABÓ Nikoletta STARČUK Zenon REKTOROVÁ Irena PAN-MONTOJO Francisco

Year of publication 2021
Type Article in Periodical
Magazine / Source Journal of Neurochemistry
MU Faculty or unit

Faculty of Medicine

Citation
Web https://onlinelibrary.wiley.com/doi/10.1111/jnc.15449
Doi http://dx.doi.org/10.1111/jnc.15449
Keywords alpha synuclein, diffusion kurtosis imaging, MRI, Parkinson, rotenone, s disease, tract-based spatial statistics
Description We test the utility and sensitivity of the diffusion kurtosis imaging (DKI) in detecting progressive microstructural changes in several brain regions of mice exposed to chronic intragastric administration of rotenone,a mouse model that mimics the spatiotemporal progression of PD-like pathology from the ENS to the SN as described by Braak's staging.
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