TaqI A polymorfismus genu pro dopaminový receptor D2 a alkoholismus v České republice

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Title in English TaqI A polymorphism of the DRD2 gene and alcoholism in the Czech Republic
Authors

KAŠPAROVSKÁ Jitka HŘÍBKOVÁ Hana HLOUŠKOVÁ Renáta NOVOTNÝ Miroslav GLÁSLOVÁ Kateřina ŠIMEK Vladimír MIKEŠ Vladimír ZVOLSKÝ Petr ŠERÝ Omar

Year of publication 2003
Type Article in Periodical
Magazine / Source Česká a slovenská psychiatrie
MU Faculty or unit

Faculty of Science

Citation
Field Psychiatry, sexuology
Keywords TaqI A polymorphism; DRD2; alcoholism; alcohol dependence; association
Description In this study 571 persons were included (280 alcoholics and 291 controls). The diagnostic criteria DSM-IV and ICD-10 for the diagnosis of alcoholism were used. The genomic DNA from the blood using the commercial kit UltraClean Blood Spin kit (MoBio, USA) was isolated. PCR and RFLP for genotypisation were used. We found the same frequency of the A1 allele in alcoholics and controls (0,18). Statistically significant difference in the frequency of the A1 allele was observed between males and females in control group (p = 0.038). No association of the TaqI A polymorphism to the alcohol dependence in the Czech Republic was found.
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