Fading of the inhibition of CYP2D6 after paroxetine treatment discontinuation
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | European Neuropsychopharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | disinhibition; CYP2D6; paroxetine; poor metaboliser; phenotype; genotype |
| Description | The study unswers an important question: how long persists the inhibition after paroxetine treatment? The inhibition of CYP2D6 could exclude any substrates of CYP2D6 from the therapy. 4 weeks period seem to be sufficient for restoration of metabolic activity of CYP2D6. |
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