Kinetika hematopoesy po vysokodávkované chemoterapii a autologní transplantaci periferních kmenových buněk

• Title in English: Kinetics of hematopoiesis after high-dose chemotherapy and autologous peripheral stem cell transplantation
• Authors: MAYER Jiří; KOŘÍSTEK Zdeněk; POSPÍŠIL Z.; VÁŠOVÁ Ingrid; ADAM Zdeněk; HÁJEK Roman; KREJČÍ Marta; KRÁL Z.; NAVRÁTIL M.; VORLÍČEK Jiří; BOURKOVÁ L.; MATÝSKOVÁ M.; ADLER J.; VINKLÁRKOVÁ J.; KLABUSAY Martin; KOUTNÁ I.; HOFFOVÁ V.; SCHMITZOVÁ D.; JANOVSKÁ E.
• Year of publication: 1999
• Type: Article in Periodical
• Magazine / Source: Časopis lékařů českých
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: Autologous peripheral blood stem cell transplantation
• Description: Autologous peripheral blood stem cell transplantation (APBSCT) is gradually replacing autologous bone marrow transplantation in many clinical settings. The key question is how to evaluate the quality of grafts. We analyzed the relationship between hematopoietic reconstitution and characteristics of patients and grafts. CONCLUSIONS: We conclude that the content of progenitors in PBSC grafts and time to booth leukocyte and platelet recovery are best estimated by the number of CD34+ cells (not less than 1 x 10(6)/kg) and CFU-GM (not less than 1 x 10(4)/kg). The number of mononuclear cells in an autologous PBSC graft is not suitable and useful for prediction of engraftment rate. There is probably no additional benefit of reinfusion of more than 8-10 x 10(6) CD34+ cells/kg and/or 50 x 10(4) CFU-GM/kg, because hematopoietic recovery is not more rapid.