Účinnost terapie pegylovaným interferonem a ribavirinem u pacientů s chronickou HCV infekcí
| Title in English | Efficacy of combination treatment with pegylated interferon plus ribavirin in patients chronically infected with HCV |
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| Authors | |
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Epidemiology, infectious diseases and clinical immunology |
| Keywords | hepatitis C;pegylated interferon;ribavirin |
| Description | The aim of study: To evaluate the efficacy of combined antiviral treatment with pegylated interferon alpha plus ribavirin in patients with chronic HCV infection who have not yet been treated with antivirals. To compare the treatment effect in patients with low (< 600,000 IU/ml) and high (>= 600,000 IU/ml) initial viremia. Results: In the genotype 1 group (n=124), 76% of patients achieved end of treatment response and 59% of patients achieved sustained viral response. Both types of response were observed in 100% of the genotype 2 and 3 infected patients (n=7). Conclusion: The results observed in the present study are generally slightly better than comparable results form large registration studies. In contrary to the published literature, the threshold of 600,000 IU/ml for initial viremia did not correlate statistically significantly with SVR. |