Phosphoinositide 3-kinase inhibition enables retinoic acid-induced neurogenesis in monolayer culture of embryonic stem cells.

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Authors

KOTASOVÁ Hana VESELÁ Iva KUČERA Jan HOUDEK Zbyněk PROCHÁZKOVÁ Jiřina KRÁLÍČKOVÁ Milena PACHERNÍK Jiří

Year of publication 2012
Type Article in Periodical
Magazine / Source J Cell Biochem
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1002/jcb.23380
Field Physiology
Keywords Embryonic stem cell;retionic acid;neurogenesis;differentiation
Description Retinoic acid is able to induce the differentiation of embryonic stem cells into neuronal lineages. The mechanism of this effect is unknown but it has been evidenced to be dependent on the formation of floating spheroids called embryoid bodies. Results presented here show that the inhibition of phosphoinositide 3-kinase signaling predetermines mouse embryonic stem cells to retinoic acid induced neurogenesis in monolayer culture with no need of embryoid bodies formation.
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