Localization of the STAT3 binding site in the MDR1 enhanceosom

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Authors

ŠRÁMKOVÁ Zuzana PROCHÁZKOVÁ Jiřina KOTASOVÁ Hana TMEJOVÁ Kateřina GUDERNOVÁ Iva PACHERNÍK Jiří

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description The work evidenced that STAT3-induced over-expression of MDR1 is dependent on area assigned *824, so we can conclude that in this area is localized the crucial STAT3 binding site. Area *824 contains direct repeat with a three-nucleotide spacer and a three direct repeats with four-nucleotide spacer. Previous studies have shown that pregnane X receptor and constitutive androstane receptor, members of the nuclear receptor superfamily, as well as thyroid hormone receptors, mediate the up-regulation of MDR1 through this response region located -7.9 to -7.8 kb upstream of the MDR1 using an epithelial cell line LS174T or Caco2 (Burk et al., 2005; Geick et al., 2001; Kurose et al. 2008). This illustrates the general importance of this enhancer region upstream of MDR1 gene.
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