Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture

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Year of publication 2013
Type Article in Periodical
Magazine / Source Experimental Biology and Medicine
MU Faculty or unit

Faculty of Medicine

Doi http://dx.doi.org/10.1177/1535370213480711
Field Genetics and molecular biology
Keywords human embryonic stem cells; cell cycle; culture adaptation; long-term culture
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Description Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.
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