Cykliny D v regulaci a dysregulaci buněčného cyklu u mnohočetného myelomu

Title in English Cyclins D in regulation and dysregulation of the cell cycle in multiple myeloma
Authors

KUBICZKOVÁ Lenka DÚCKA Monika SEDLAŘÍKOVÁ Lenka KRYUKOV Fedor HÁJEK Roman ŠEVČÍKOVÁ Sabina

Year of publication 2013
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Cell cycle regulation; Cyclin D; Multiple myeloma; Pathogenesis; TC groups
Description Multiple myeloma is the second most common hematooncological disease characterized by clonal proliferation of plasma cells and monoclonal immunoglobulin production. It is a heterogenous disease; however, dysregulation of cyclins D seems to be an early unifying pathogenic event in multiple myeloma. In almost all patients, there is increased expression level of at least one of the cyclins D. Nevertheless, the mechanism of this increase is unknown in many cases. Next to well-known roles of cyclins D in the cell cycle, they have many other functions contributing to tumor cell progression. Cyclins D are prognostic markers and are also used for subclassification of multiple myeloma. In this review, we focus on significance of cyclins D in multiple myeloma.
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