Impact of vaccination on the course of recurrent laryngeal papillomatosis - case report
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| Year of publication | 2014 |
| Type | Conference abstract |
| MU Faculty or unit | |
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| Description | We present a case report of one year old girl with recurrent laryngeal papillomatosis that was successfully treated by vaccination. The childs mother got condyloma acuminata during pregnancy. The disease was transmitted to the girl probably during delivery. At age of 5 months, the child started to present difficulties with breathing due to laryngeal papilomas. The disease required frequent papilectomies (almost every month) to maintain breathing. The papilomavirus type 11 was detected by PCR in the papiloma histology sample. At age of 18 months we started experimental vaccination with Gardasil* (it contains particles similar to HPV 6, 11, 16, 18). Intervals between necessary papilectomies were longer after the second dose of the vaccine. There was no need for further polypectomy after the third dose of the vaccine. At age of 30 months the child has no clinical and laryngoscope signs of laryngeal papillomatosis and the girl regained her voice. This case indicates possible new therapeutical approach to recurrent laryngeal papillomatosis. |