The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

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Authors	MALČÍKOVÁ Jitka STALIKA Evangelia DAVIS Zadie PLEVOVÁ Karla TRBUŠEK Martin MANSOURI Larry SCARFO Lydia BALIAKAS Panagiotis GARDINER Anne SUTTON LA FRANCOVA Hana Skuhrová AGATHANGELIDIS Andreas ANAGNOSTOPOULOS Achilles TRACY Ian MAKRIS Antonis ŠMARDOVÁ Jana GHIA Paolo BELESSI Chrysoula GONZALEZ David ROSENQUIST Richard OSCIER David POSPÍŠILOVÁ Šárka STAMATOPOULOS Kostas
Year of publication	2014
Type	Article in Periodical
Magazine / Source	British Journal of Haematology
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://onlinelibrary.wiley.com/doi/10.1111/bjh.12893/abstract
Doi	http://dx.doi.org/10.1111/bjh.12893
Field	Oncology and hematology
Keywords	chronic lymphocytic leukaemia; immunoglobulin genes; stereotyped B cell receptors; TP53 mutations; prognosis
Attached files	ZVV_2014_143_1216535_The_frequency_of_TP53.pdf
Description	In chronic lymphocytic leukaemia (CLL) tumour initiation and progression are linked to the interplay between cellextrinsic and cell-intrinsic mechanisms. Cell-extrinsic mechanisms relate to the crosstalk of CLL cells with their microenvironment through various receptors, including the B-cell receptor (BcR).
Related projects:	SuPReMMe - Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny CEITEC - Central European Institute of Technology Molekulární charakterizace B buněčných receptorů a jejich vztah k evoluci genetických změn u chronické lymfocytární leukémie Časná identifikace CLL pacientů s dosud nevyselektovanými mutacemi v proteinu p53