Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation

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Authors

ANDERKOVÁ Ľubomíra ELIÁŠOVÁ Ilona MAREČEK Radek JANOUŠOVÁ Eva REKTOROVÁ Irena

Year of publication 2015
Type Article in Periodical
Magazine / Source JOURNAL OF ALZHEIMERS DISEASE
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067
Doi http://dx.doi.org/10.3233/JAD-150067
Field Neurology, neurosurgery, neurosciences
Keywords noninvasive brain stimulation; Alzheimer's disease; cognitive functions; brain atrophy; source-based morphometry
Attached files
Description Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to study and modulate brain plasticity. Objective: Our aim was to investigate the effects of rTMS on cognitive functions in patients with mild cognitive impairment and Alzheimer’s disease (MCI/AD) and assess the effect of gray matter (GM) atrophy on stimulation outcomes. Methods: Twenty MCI/AD patients participated in the proof-of-concept controlled study. Each patient received three sessions of 10 Hz rTMS of the right inferior frontal gyrus (IFG), the right superior temporal gyrus (STG), and the vertex (VTX, a control stimulation site) in a randomized order. Cognitive functions were tested prior to and immediately after each session. The GM volumetric data of patients were: 1)compared to healthy controls (HC) using source-based morphometry; 2) correlated with rTMS-induced cognitive improvement. Results: The effect of the stimulated site on the difference in cognitive scores was statistically significant for the Word part of the Stroop test (ST-W, p = 0.012, linear mixed models). As compared to the VTX stimulation, patients significantly improved after both IFG and STG stimulation in this cognitive measure. MCI/AD patients had significant GM atrophy in characteristic brain regions as compared to HC (p = 0.029, Bonferroni corrected). The amount of atrophy correlated with the change in ST-W scores after rTMS of the STG. Conclusion: rTMS enhanced cognitive functions in MCI/AD patients. We demonstrated for the first time that distinct pattern of GM atrophy in MCI/AD diminishes the cognitive effects induced by rTMS of the temporal neocortex.
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