Sequencing analysis of PAX9 and MSX1 genes in the Czech population

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Authors

BONCZEK Ondřej ŠERÝ Omar HLOUŠKOVÁ Alena LOCHMAN Jan IZAKOVIČOVÁ HOLLÁ Lydie ŠOUKALOVÁ Jana ŠTEMBÍREK Jan MÍŠEK Ivan ČERNOCHOVÁ Pavlína KREJČÍ Přemysl VANĚK Jiří

Year of publication 2015
Type Article in Proceedings
Conference Morphology 2015
MU Faculty or unit

Faculty of Science

Citation
Web Biomedical Papers, volume 159, Supplement 1
Doi http://dx.doi.org/10.5507/bp.2015.042
Field ORL, ophthalmology, stomatology
Keywords PAX9; MSX1; tooth agenesis; oligodontia; mutation screening
Description Tooth agenesis is one of the most common de- velopmental anomalies in humans. Tooth development (odontogenesis) is a very complicated and complex pro- cess that involves interplay between oral ectoderm and mesenchyme. These interactions are mediated by more than 350 signaling proteins. Synergistic and antagonistic interactions between these proteins may lead to local ac- tivation or inhibition of the expression. The aim of our study was to investigate the relationship between PAX9 and MSX1 genes variants and tooth agenesis in the Czech population.
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