Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Biochemistry Research International |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1155/2015/617620 |
| Field | Biochemistry |
| Keywords | Escholzia californica; alkaloids; gaba receptors; mass spectrometry |
| Description | The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected in E. californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons. |