Mikroprostředí nádoru – možnosti výzkumu v podmínkách in vitro

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Title in English Tumor microenvironment – possibilities of the research under in vitro conditions
Authors

CHLAPEK Petr CHOVANOVÁ Silvia SLÁVIKOVÁ Viera VESELSKÁ Renata

Year of publication 2014
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords tumor microenvironment; hypoxia; acidic pH; glucose deprivation; in vitro conditions
Description Tumorigenesis is always accompanied by alterations of the microenvironment in the respective tissue. The tumor microenvironment represents a heterogeneous complex, in which cell proliferation, differentiation, necrosis or apoptosis are regulated by various extracellular stimuli, and it can also lead to development of an aggressive phenotype of tumor cells. Influence of tumor microenvironment is also often connected with resistance to frequently used therapeutic procedures. Specifics of the tumor microenvironment are closely associated with the structural and functional abnormalities of tumor microvessels and altered cellular metabolism. Moreover, changes such as increase in glycolysis, elevated glucose uptake, production of lactate and CO2, and presence of hypoxic regions and regions with acidic pH are typical features of tumor tissues. At present, there is a lot of methods for in vitro simulation and investigation of some of these specific conditions, and a number of new methods are being developed. A detailed understanding of the specifics of the tumor microenvironment should increasingly improve the development of new treatment possibilities of human cancers.
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