The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study

Investor logo
Investor logo

Warning

This publication doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors

ŠTILLOVÁ Klára JURÁK Pavel CHLÁDEK Jan CHRASTINA Jan HALÁMEK Josef BOČKOVÁ Martina GOLDEMUNDOVÁ Sabina ŘÍHA Ivo REKTOR Ivan

Year of publication 2015
Type Article in Periodical
Magazine / Source PLOS ONE
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140778
Doi http://dx.doi.org/10.1371/journal.pone.0140778
Field Neurology, neurosurgery, neurosciences
Keywords ANT; anterior nuclein of the thalamus; deep brain stimulation; epilepsy
Attached files
Description Objective To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks. Methods We studied intracerebral recordings in patients with pharmacoresistent epilepsy who underwent deep brain stimulation (DBS) of the ANT with depth electrodes implanted bilaterally in the ANT and compared the results with epilepsy surgery candidates with depth electrodes implanted bilaterally in the hippocampus. We recorded the event-related potentials (ERPs) elicited by the visual and verbal memory encoding and recognition tasks. Results P300-like potentials were recorded in the hippocampus by visual and verbal memory encoding and recognition tasks and in the ANT by the visual encoding and visual and verbal recognition tasks. No significant ERPs were recorded during the verbal encoding task in the ANT. In the visual and verbal recognition tasks, the P300-like potentials in the ANT preceded the P300-like potentials in the hippocampus. Conclusions The ANT is a structure in the memory pathway that processes memory information before the hippocampus. We suggest that the ANT has a specific role in memory processes, especially memory recognition, and that memory disturbance should be considered in patients with ANT-DBS and in patients with ANT lesions. ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info