Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling

Investor logo
Investor logo

Warning

This publication doesn't include Faculty of Medicine. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors

ŠVACHOVÁ Veronika VOJTOVÁ Lucy PAVLIŇÁK David VOJTEK Libor SEDLÁKOVÁ Veronika HYRŠL Pavel ALBERTI Milan JAROŠ Josef HAMPL Aleš JANČÁŘ Josef

Year of publication 2016
Type Article in Periodical
Magazine / Source Materials Science & Engineering C-Materials for Biological Applications
MU Faculty or unit

Faculty of Science

Citation
Web odkaz na článek
Doi http://dx.doi.org/10.1016/j.msec.2016.05.059
Field Macromolecular chemistry
Keywords Oxycellulose;Gelatin;Electrospinning;Nanofibers;Regenerative medicine;Antibacterial
Description Novel hydrolytically stable gelatin nanofibers modified with sodium or calcium salt of oxycellulose were prepared by electrospinning method. The unique inhibitory effect of these nanofibers against Escherichia coli bacteria was examined by luminometric method. Biocompatibility of these gelatin/oxycellulose nanofibers with eukaryotic cells was tested using human lung adenocarcinoma cell line NCI-H441. Cells firmly adhered to nanofiber surface, as determined by scanning electron microscopy, and no signs of cell dying were detected by fluorescent live/dead assay. We propose that the newly developed gelatin/oxycellulose nanofibers could be used as promising scaffold for lung disease modeling and anti-cancer drug testing.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info