Moderní terapie dny
| Title in English | Modern treatment of gout |
|---|---|
| Authors | |
| Year of publication | 2016 |
| Type | Article in Proceedings |
| Conference | Aktuality z vnitřního lékařství 2016 : XXIII. kongres České internistické společnosti ČLS J. E. Purkyně 21.-24. 9. 2016 |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | gout; hyperuricemia; uric acid; therapy |
| Description | Gout is a serious metabolic disease, which is characterized by the formation and deposition of crystals of sodium urate in various tissues. Hyperuricemia is a pathological increase in serum uric acid concentration. Gout affects approximately 1-2% of the adult population in developed countries, and its prevalence has been increasing in recent decades. Despite our knowledge of the pathogenesis and clinical manifestation of the disease, gout is not diagnosed correctly and early, treatment is not well managed, which could result in damage to the structure and function of joints, damage to kidney function with a subsequent increase in morbidity and mortality, and reduced quality of life of patients. Hyperuricemia is a major independent risk factor for the development of gout. An acute gout attack may be an early manifestation of gout. Chronic tophaceous gout is referred to as a state when the structures of the musculoskeletal system are destroyed by the deposition of sodium urate crystals. Modern treatment of gout includes treatment of asymptomatic hyperuricemia, acute gout flare treatment, treatment of the intercritical period and chronic tophaceous gout and, also, prophylactic treatment of gout flares. Reduction and long-term maintenance of serum uric acid concentrations below 360 umol/l are preconditions for successful treatment of gout which allows the dissolution of urate deposits in tissues and prevents their formation. |