Uterine Fibroid Morphology and Histology with Respect to Reproductive Age
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | The Journal of Reproductive Medicine |
| MU Faculty or unit | |
| Citation | |
| Field | Gynaecology and obstetrics |
| Keywords | fibroid; fibroid tumor; fibroid uterus; fibroma uterine; gynecologic surgical procedures; histology; leiomyoma; uetrine fibroid; uterine myomestomy |
| Description | OBJECTIVE: To evaluate histological uterine fibroid incidence among reproductive age women and to determine correlations between fibroid histological type, patient age, and number and size of fibroids. STUDY DESIGN: The study cohort consisted of 103 women desiring pregnancy who underwent myomectomy for symptomatic uterine fibroids. The primary endpoints were histological type of fibroid, myomectomy incidence among 2 age groups (18-34 vs. 35-40), solitary or multiple fibroids, and <5 cm vs. >5 cm fibroid diameter. Secondary analysis endpoints evaluated correlations between uterine fibroid histological type, 2 age groups of women, and uterine fibroid number and size. RESULTS: Following myomectomy, 84.5% exhibited benign histology, and myomatosis malignancy was not detected. Of the 103 women, 50.5% were aged <34 and 49.5% were aged 35-40; 71.8% had a solitary fibroid and 28.2% had a >= 2 fibroids; 58.3% had a fibroid of <5 cm and 41.7% had a fibroid >5 cm in diameter. Cellular fibroid incidence was higher (10.3%) in cases of multiple myomatosis in comparison to the solitary fibroid group (n=0) (p=0.021). Among women with multiple myomatosis (n=29), almost all (n=28, 96.6%) had only 1 histological type. CONCLUSION: Among women of child-bearing age having myomectomy, most have benign histology with no significant differences in histological type with regard to patient age and fibroid size. A higher incidence of cellular fibroids was observed only in multiple myomatosis cases. |