Polymorphisms in Vitamin D Receptor Gene in Orthodontic Patients with External Apical Root Resorption

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Year of publication 2016
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Medicine

Description AIMS: To investigate possible links between single nucleotid polymorphisms in vitamin D receptor gene and root resorption after orthodontic treatment. SUBJECTS AND METHOD: One hundred children were included in this study (31 patients aged 10 ± 4.1 years with external apical root resorption greater than 2 mm on panoramic radiographs after orthodontic treatment and 69 patients aged 12 ± 3 years without resorption). DNA was analyzed with real-time polymerase chain reaction for TaqI, BsmI, ApaI, FokI and Cdx2 polymorphisms. The obtained genotypes were evaluated in relation to gender, age, skeletal Class and the type of orthodontic treatment. RESULTS: No statistically significant differences were found between patients with and without resorption concerning occurrence of alleles or genotypes for each polymorphism. In a more detailed analysis, marginally important differences (trends) were observed for the frequencies of ApaI (P = 0.059) and the haplotype TGCTA (P = 0.063) in boys. CONCLUSION: Even though a significant role of vitamin D receptor gene polymorphisms was not established in girls, more research is needed in boys. In this small cohort of patients no associations of vitamin D receptor polymorphisms in girls were observed. In boys more research in needed as the slight trends observed imply possible associations of vitamin D polymorphisms with external apical root resorption.
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