LA-ICP-MS as a tool for imaging of tumour tissue

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Authors

VACULOVIČ Tomáš TVRDOŇOVÁ Michaela MASAŘÍK Michal POLANSKÁ Hana SVOBODOVÁ Markéta KANICKÝ Viktor

Year of publication 2016
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Science

Citation
Description Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) allows study of lateral distribution of specific elements (Cu, Zn, Pb, Pt) in very low concentration levels (mg/kg) in tumor tissues. Presented work is focused on study of laser ablation parameters (scan speed and laser spot diameter) on lateral resolution and limit of detection of LA-ICP-MS. The utilization of LA-ICP-MS for bioimaging purpose will be demonstrated on mice tumour tissues analysis which are treated by various Pt-based cytostatics (carbo-, oxali- and cis-Pt).
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