Impulse control disorders in patients with young-onset Parkinson's disease: A cross-sectional study seeking associated factors


GESCHEIDT Tomáš LOSADA Veronika Ibarburu L. Y. MENŠÍKOVÁ Kateřina DUŠEK Ladislav CZEKÓOVÁ Kristína MENCLOVÁ Petra KAŇOVSKÝ Petr ROTH Jan BAREŠ Martin

Year of publication 2016
Type Article in Periodical
Magazine / Source Basal Ganglia
MU Faculty or unit

Faculty of Medicine

Field Neurology, neurosurgery, neurosciences
Keywords Parkinson's disease; Impulse control disorders; Pathological gambling; Dopamine agonists; Personality
Attached files
Description Introduction: The aim of this cross-sectional study was to investigate the frequency and factors associated with impulse control disorder (ICD) symptoms, including personality characteristics, in Czech young-onset Parkinson's disease (PD) patients. Subjects and methods: We examined 49 young-onset PD patients and 38 age-matched control subjects. ICD symptoms were identified using the South Oaks Gambling Screen and modified Minnesota Impulse Disorders Interview. Results: A higher prevalence of pathological gambling and hypersexuality was found in PD patients than in control subjects. A higher frequency of pathological gambling in our sample of young-onset PD patients was found in patients using dopamine agonists and in patients with dyskinesias lasting 5 or more years. The frequency of any ICD symptom was associated with coffee consumption, higher reported anxiety, and somatization. ICD symptoms were also related to personality characteristics in PD patients; specifically, patients who manifested any ICD symptom scored significantly higher on Self-assertive/ Antisocial and Reserved/Schizoid personality styles and pathological gambling was associated with lower reported Conscientiousness. Conclusion: Our results demonstrate that ICD presents a real problem in young-onset PD patients. Knowledge about the factors associated with ICD symptoms might be helpful in the proactive search for these pathological behaviours in this specific subgroup of PD patients.
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