SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | POLISH JOURNAL OF PATHOLOGY |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.5114/pjp.2017.73931 |
| Keywords | neuroendocrine tumor; malignant paraganglioma; hereditary syndromes; thyroid transcription factor 1 |
| Description | Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary. |