Subtype definition of vascular parkinsonism

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Authors	REKTOR Ivan BOHNEN N.I. KORCZYN A.D.
Year of publication	2018
Type	Article in Periodical
Magazine / Source	PARKINSONISM & RELATED DISORDERS
MU Faculty or unit	Central European Institute of Technology
Citation
Doi	http://dx.doi.org/10.1016/j.parkreldis.2018.03.005
Keywords	OLDER-ADULTS; DISEASE; DENERVATION; SIGNS
Description	We thank Dr. Levin for expressing interest in our work. Dr. Levin applies a traditional clinico-anatomic perspective to interpret our proposed criteria, pointing out that our criteria do not exclusively require that vascular lesions be located within specific topographic regions, such as the nigrostriatal and striato-thalamo-cortical pathways. At the same time, Dr. Levin notes the often observed clinical scenario in which patients with extensive and confluent vascular lesions on brain MRI scans may be fully asymptomatic motor-wise despite the fact that some of these lesions may be located in regions of critical motor circuitry. This scenario shows that factors other than the geographic location of vascular lesions in the brain may play a role in the pathogenesis of vascular parkinsonism (VaP).