Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties

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This publication doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

SOJKA Martin FOJTŮ Michaela FIALOVÁ Jindřiška MASAŘÍK Michal NEČAS Marek MAREK Radek

Year of publication 2019
Type Article in Periodical
Magazine / Source Inorganic Chemistry
MU Faculty or unit

Central European Institute of Technology

Web DOI: 10.1021/acs.inorgchem.9b01203
Doi http://dx.doi.org/10.1021/acs.inorgchem.9b01203
Keywords metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic
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Description We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system was determined by X-ray diffraction. Because the biological properties of Ru-based metallodrugs are tightly linked to the ligand-exchange processes, the effect of salt concentration on the hydrolysis of chlorides from the Ru(II) center was monitored by using 1H NMR spectroscopy. The biological activity of Ru(II)-based rotaxanes was evaluated for three selected mammalian breast cell lines, HBL-100, MCF-7, and MDA-MB-231. The antimetastatic activity of the assembled cationic Ru(II)-rotaxane systems, evaluated in migration assays against MCF-7 and MDA-MB-231 cell lines, is notably enhanced compared to that of RAPTA-C, a reference that was used. The indicated synergistic effect of combining Ru(II) with a pseudorotaxane unit opens a new direction in searching for anticancer supramolecular metallodrugs.
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