Ozonization of Tissue Sections for MALDI MS Imaging of Carbon-Carbon Double Bond Positional Isomers of Phospholipids

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Authors

BEDNAŘÍK Antonín PREISLER Jan BEZDEKOVÁ Dominika MACHÁLKOVÁ Markéta HENDRYCH Michal NAVRÁTILOVÁ Jarmila KNOPFOVÁ Lucia MOSKOVETS Eugene SOLTWISH Jens DREISEWERD Klaus

Year of publication 2020
Type Article in Periodical
Magazine / Source Analytical Chemistry
MU Faculty or unit

Faculty of Science

Citation
Web https://pubs.acs.org/doi/abs/10.1021/acs.analchem.0c00641
Doi http://dx.doi.org/10.1021/acs.analchem.0c00641
Keywords ozonolysis; MALDI MS imaging; double bond positional isomers; phospholipids; colon
Description A particular traightforward derivatization technique for an on-tissue ozonization that enables MALDI MS/MS imaging of C=C double bond isomers of unsaturated phospholipids in tissue sections was developed.
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