Ozonization of Tissue Sections for MALDI MS Imaging of Carbon-Carbon Double Bond Positional Isomers of Phospholipids

Warning

This publication doesn't include Faculty of Medicine. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	BEDNAŘÍK Antonín PREISLER Jan BEZDEKOVÁ Dominika MACHÁLKOVÁ Markéta HENDRYCH Michal NAVRÁTILOVÁ Jarmila KNOPFOVÁ Lucia MOSKOVETS Eugene SOLTWISH Jens DREISEWERD Klaus
Year of publication	2020
Type	Article in Periodical
Magazine / Source	Analytical Chemistry
MU Faculty or unit	Faculty of Science
Citation
Web	https://pubs.acs.org/doi/abs/10.1021/acs.analchem.0c00641
Doi	http://dx.doi.org/10.1021/acs.analchem.0c00641
Keywords	ozonolysis; MALDI MS imaging; double bond positional isomers; phospholipids; colon
Description	A particular traightforward derivatization technique for an on-tissue ozonization that enables MALDI MS/MS imaging of C=C double bond isomers of unsaturated phospholipids in tissue sections was developed.
Related projects:	CEITEC 2020 Optimalizace cílené terapie kolorektálního karcinomu ovlivňováním účinnosti penetrace a cytotoxicity regulátorů buněčných signalizací MALDI MS zobrazování izomerů lipidů lišících se pozicí dvojné vazby uhlík-uhlík