Trop2: Jack of All Trades, Master of None

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Authors

LENÁRT Sára LENÁRT Peter ŠMARDA Jan REMŠÍK Ján SOUČEK Karel BENEŠ Petr

Year of publication 2020
Type Article in Periodical
Magazine / Source Cancers
MU Faculty or unit

Faculty of Science

Citation
Web https://doi.org/10.3390/cancers12113328
Doi http://dx.doi.org/10.3390/cancers12113328
Keywords Trop2; TACSTD2; cancer; proliferation; metastases; epithelial-to-mesenchymal transition; therapy
Attached files
Description Trophoblast cell surface antigen 2 (Trop2) is a widely expressed glycoprotein and an epithelial cell adhesion molecule (EpCAM) family member. Although initially identified as a transmembrane protein, other subcellular localizations and processed forms were described. Its congenital mutations cause a gelatinous drop-like corneal dystrophy, a disease characterized by loss of barrier function in corneal epithelial cells. Trop2 is considered a stem cell marker and its expression associates with regenerative capacity in various tissues. Trop2 overexpression was described in tumors of different origins; however, functional studies revealed both oncogenic and tumor suppressor roles. Nevertheless, therapeutic potential of Trop2 was recognized and clinical studies with drug-antibody conjugates have been initiated in various cancer types. One of these agents, sacituzumab govitecan, has been recently granted an accelerated approval for therapy of metastatic triple-negative breast cancer. In this article, we review the current knowledge about the yet controversial function of Trop2 in homeostasis and pathology.
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