Granulation Tissue Enhanced with Aspirin and Omega-3 PUFAs as a Local Adjunct to the Surgical Treatment of Periodontitis



Year of publication 2021
Type Article in Periodical
Magazine / Source European Journal of Lipid Science and Technology
MU Faculty or unit

Faculty of Medicine

Web záznam na stráce vydavatele
Keywords aspirin; granulation tissues; omega3 polyunsaturated fatty acids; periodontitis; regeneration
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Description The topical application of aspirin and omega-3 polyunsaturated fatty acids(PUFAs) may trigger the resolution of inflammation by inducing thebiosynthesis of proresolvers such as lipoxins and resolvins while alsoavoiding the side effects of systemic aspirin intake. This study assessed theeffect of enhanced granulation tissue (EGT) on periodontal tissue regeneration through the local application of aspirin and omega-3 PUFAs directly to granulation tissue (GT) during periodontal surgery. Thisrandomized controlled experiment assesses 38 pockets in 19 patients. In every patient, two similar intrabony periodontal defects are treated with an open flap debridement, one with EGT (GT extracted, enhanced with aspirin and omega3 PUFAs, and replaced) and the other with standard GT removal. Clinical attachment level (CAL) and probing pocket depth (PPD) are assessed at baseline and 2 and 6 months after surgery. The experimental protocol (EGT) results in a greater CAL gain as compared to that in the controls at 6 months (p < 0.05), while PPD reduction is not affected. The retained GT does not compromise healing. EGT is proposed as a promising, inexpensive, and simple method that may improve the outcome of periodontal regenerative treatment. However, the described protocol requires optimization and further assessment.
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