| Description |
The clinical everyday management of blood pressure (BP) and heart rate (HR) can be greatly improved by the mapping of time structures in home ambulatory BP and HR assessment Thereby, we change focus from the BP and the HR to the dynamics of these variables. This change is achieved by computerimplemented chronomics, the mapping of chronomes, consisting of cyclicities (our concern herein) along with chaos and trends, in the service of cardiologists, general health care providers and the educated public. We here further illustrate the yield of chronomics in research on long BP and HR series covering years, some several decades long, and on archives of human sudden cardiac death and coronary heart disease (1-8). Variabilities, a formidable foe and confounder (9-15) when ignored, can be computer-resolved into chronomes - clinically informative time structures (16-21). As yet, any variability is currently largely ignored in countries with resources. There, research on high BP is largely dominated by the pharmaceutical industry and the National Institutes of Health, providing funds for clinical trials and guidelines derived from these trials are used for the public at large (22-25). At entry into a trial, the BP of very many adults is usually measured without any recording of timing, without any specific consideration of age group or ethnicity, and often ignoring gender even at the most renowned clinics (22-25). Measurements may be made only on a few occasions, if not only once. A chronobiologic approach to variability by sphygmochrons is already implemented in locations with limited resources, such as Armenia, China and India, with measurements beyond 24 hours, the target being 7-day records. In cooperation with Halberg Chronobiology Center of University of Minnesota USA, between the years 1988 and 2014, the Brno chronobiology team consisting of Prof. Fiser, Dr. Dusek and Prof. Siegelova collected 75 029 sets of seven day ambulatory blood pressure monitoring and data from blood pressure and heart rate measurements were in the following day send and analyzed by Prof. G. Cornélissen from University of Minnesota, USA.
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